Provided are novel use of an extract of Lycoris chejuensis or a compound isolated therefrom for inhibition of ²-amyloid production and/or prevention, improvement and/or treatment of a neurodegenerative disease, more specifically a ²-amyloid production inhibitor, and/or a composition for prevention or treatment of a neurodegenerative disease containing one or more kinds selected from the group consisting of an extract of Lycoris chejuensis, and/or dihydrolycoricidinc, 2-methoxypancracinc, lycoricidine, and/or lycoricidinol, as an active ingredient； a method for inhibiting ²-amyloid production, and/or preventing and/or treating a neurodegenerative disease using the same； and, a method for preparing the same.제주상사화(Lycorischejuensis) 추출물, 및/또는 이로부터 분리된 디하이드로라이코리시딘, 2-메톡시판크라신, 라이코리시딘 및/또는 라이코리시디놀을 유효성분으로 함유하는 퇴행성 신경 질환의 예방, 개선, 및/또는 치료용 조성물 및 건강기능성 식품, 및 이들의 제조방법이 제공된다.
