Utilisation combinée d'un agent bloquant CTLA-4 et d'une thérapie lymphotoxique dans le traitement des tumeurs

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专利权人:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人:

申请号：

EP10180032.4

公开号：

EP2332561B1

申请日:

1996.12.04

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

T Cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.

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