A sanitizing device for toothbrushes is described. The device has a lower housing body, and a vessel for containing a sanitizing liquid being connected to the lower housing body in an upper position according to a vertical axis. The lower housing body has removable basins adapted to contain a head of the toothbrush substantially arranged along the vertical axis. The removable basins are hydraulically connected to the vessel for the controlled flowing down of the sanitizing liquid from the vessel to the basins. The lower housing body is removably associated to a cap in an upper position according to the vertical axis, the cap being cup-shaped to enclose the vessel and possible portions of the toothbrush that project upwards from the lower body.