< Topic >Being stabilized vis-a-vis heat, and light conservation is good, in addition skin permeability is high, adding water resolution rapidly by the phosphatase which it is distributed to in vivo widely, furthermore be able to show hydroxy phenol original useful physiological activity, security to the skin is high at the same time adding water with the anti- inflammation effect of the specified anti- oxidizer resolution, furthermore the new poly hydroxy benzene derivative whose skin irritation is low or it is to make the skin external use medicine or the whitening cosmetics which for the anti- inflammation uses this. Solutions Phosphoric acid ester is made to join to hydroxyl group of the anti- oxidizer which consists of asutakisanchin, tokohueroru or tokotorienoru, this phosphoric ester hydroxyl group and diester of 1 or more of poly hydroxy benzene porihidorokishihueniruhuosuhueto which is made to join or is designated as the anti- oxidation Characteristic poly hydroxy benzene derivative which consists of that salt. It possesses the property which the anti- oxidation Characteristic poly hydroxy benzene derivative, there being a moderate lipophilicity, is easy to be incorporated inside the cell, for also skin permeability is suited. The anti- oxidation Characteristic poly hydroxy benzene derivative which is incorporated to the cell, adding water resolution in hydroxy phenol and asutakisanchin, tokohueroru or tokotorienoru by the phosphatase other enzyme and the like which it has been distributed to in vivo system, it causes the useful effect to the living body. < Choice figure >It is not【課題】熱や光に対して安定化させて保存性がよく、また皮膚浸透性が高く、生体内に広く分布するフォスファターゼによって速やかに加水分解され、しかもヒドロキシフェノール本来の有用な生理活性を発揮でき、かつ加水分解された所定の抗酸化性物質の抗炎症効果により皮膚への安全性が高く、さらに皮膚刺激性の低い新規ポリヒドロキシベンゼン誘導体またはこれを用いた抗炎症用皮膚外用剤または美白化粧料とすることである。【解決手段】 アスタキサンチン、トコフェロールまたはトコトリエノールからなる抗酸化性物質の水酸基にリン酸をエステル結合させ、このリン酸エステルをポリヒドロキシベンゼンの1以上の水酸基とジエステル結合させたポリヒドロキシフェニルフォスフェートまたはその塩からなる抗酸化性ポリヒドロキシベンゼン誘導体とする。抗酸化性ポリヒドロキシベンゼン誘導体は、適度な脂溶性があって細胞
