The present inventions concerns derivatives of aminocyclobutane, particularly as NMDA receptor antagonists, their application in human therapy and their method of preparation. These compounds correspond to the general formula (1): wherein: X1 represents a hydrogen atom or fluorine atom； X2 is a hydrogen atom or fluorine atom or chlorine atom； R1 represents a hydrogen atom or fluorine atom or chlorine atom or methyl group or methoxy group or cyano group； R2 represents independently or together a methyl group or ethyl group.
