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METHODS FOR PREPARING HIGH THROUGHPUT PEPTIDOMIMETICS, ORALLY BIOAVAILABLE DRUGS AND COMPOSITIONS CONTAINING SAME
专利权人:
发明人:
申请号:
EP17156757.1
公开号:
EP3222720A1
申请日:
2012.08.31
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Provided herein are methods to generate and screen peptides that exhibit drug like stabilities in vitro and in vivo. By selecting for enzyme resistance, Applicants are able to derive peptides that are not only stable to a broad spectrum of proteases, but also stable to other drug processing enzymes such as cytochrome P450s. This approach provides a general method to the rapid development of highly stable peptides for therapeutic development and diagnosis. The peptides are further modified for oral bioavailability. The methods can be applied to similar peptides for the making of therapeutic compositions.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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