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polynucleotide or salt thereof, pharmaceutical composition, use of a polynucleotide or salt thereof, reagent, composition, and method for producing a compound
专利权人:
LIMITED;DAIICHI SANKYO COMPANY
发明人:
MAKIKO NAKAYAMA,MAKOTO KOIZUMI,MIKA IKEDA,YASUHIDE HIROTA
申请号:
BR112013013522
公开号:
BR112013013522A2
申请日:
2011.12.01
申请国别(地区):
BR
年份:
2019
代理人:
摘要:
It is intended to provide a polynucleotide that is resistant to RNase and has an RNA interference effect, etc. The present invention provides a single-stranded polynucleotide that is derived from a double-stranded polynucleotide comprising a sense strand polynucleotide corresponding to a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, and has a structure in which the 5'-end of the antisense strand and the 3'-end of the sense strand are linked via a phenyl group-containing linker to form a phosphodiester structure at each of these ends.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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