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PHARMACEUTICAL COMPOSITION
专利权人:
SEIKAGAKU CORPORATION
发明人:
HIROYUKI HOSOKAWA,JUNKO ODA,SOOYEOL LIM
申请号:
BR112012003149
公开号:
BR112012003149A2
申请日:
2010.08.13
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
The present invention relates to a pharmaceutical composition for relieving pain in a joint disease, including a hyaluronic acid and a pharmaceutically acceptable carrier, in which the hyaluronic acid is cross-linked by cyclizing a double bond in the moiety of a cinnamic acid in a partially amidated hyaluronic acid represented by Formula (1): [Ar-CH=CH-COO- (CH 2 ) n-NH- ] m-HA, to form a cycloubutane ring, in which Ar represents an optionally substituted phenyl group, n represents an integer of 2 or 3, HA represents a carboxy residue of the hyaluronic acid, and m represents an amidation ratio of the hyaluronic acid to the total carboxyl group and is in the range of 3 to 50% relative to the total carboxyl group. The pharmaceutical composition of the present invention is an intra-articular formulation that exerts rapid analgesic effects after administration, and shows extremely long durable effects for a human joint disease with only a single administration rather than multiple administrations of a conventional way.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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