MI SHA,PEPINSKY R. BLAKE,SHAO ZHAOHUI,GARBER ELLEN A.,MIKLASZ STEVEN D.,GRAFF CHRISTILYN,MI Sha,PEPINSKY R. Blake,SHAO Zhaohui,GARBER Ellen A.,MIKLASZ Steven D.,GRAFF Christilyn
申请号：
SI200831202
公开号：
SI2068887T1
申请日:
2008.01.09
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such as anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present disclosure provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The disclosure further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The disclosure further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.
