STOIT, Axel,IWEMA BAKKER, Wouter I.,COOLEN, Hein K.A.C.,VAN DONGEN, Maria J.P.,LEFLEMME, Nicolas J.-L.D.,HOBSON, Adrian D.
申请号：
ES11730314
公开号：
ES2606137T3
申请日:
2011.07.08
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A spiro-cyclic amine derivative of the formula (I) ** Formula ** wherein R 1 is selected from cyano, (2-4C) alkenyl, (2-4C) alkynyl, (1-4C) alkyl each optionally substituted with CN or one or more fluoro atoms, (3-6C) cycloalkyl, (4-6C) cycloalkenyl or a bicyclic (8-10C) group, each optionally substituted with halogen or (1-4C) alkyl, phenyl, biphenyl , naphthyl, each optionally substituted with one or more substituents independently selected from halogen, cyano, (1-6C) alkyl optionally substituted with one or more fluoro atoms, (1-6C) alkoxy optionally substituted with one or more fluoro atoms , amino, di (1-4C) alkylamino and (3-6C) cycloalkyl optionally substituted with phenyl which may be substituted with (1-4C) alkyl or halogen, phenyl substituted with phenoxy, benzyl, benzyloxy, phenylethyl or monocyclic heterocycle, each one optionally substituted with (1-4C) alkyl optionally substituted with one or more fluoro atoms, heteroc monocyclic iclo optionally independently substituted with halogen, (1-6C) alkyl optionally substituted with one or more fluoro atoms, (3-6C) cycloalkyl, or phenyl optionally substituted with (1-4C) alkyl or halogen, and optionally substituted bicyclic heterocycle with halogen or (1-4C) alkyl optionally substituted with one or more fluoro atoms； -Y- (Cn-alkylene) -X- is a linking group where Y is attached to R1 and selected from a bond, -O-, -CO-, -S-, -SO-, -SO2-, -NH -, -CH>； = CH-, -C (CF3)>； = CH-, - C≡C-, -CH2-O-, -O-CO-, -CO-O-, -CO-NH-, - NH-CO-, and trans-cyclopropylene； n is an integer from 0 to 10； and X is attached to the phenylene / pyridyl structural unit and selected from a bond, -O-, -S-, -SO -, - SO2-, -NH-, - CO-, -CH>； = CH-, and trans -cyclopropylene； R2 is H or independently selected from one or more substituents selected from halogen, (1-4C) alkoxy and (1-4C) alkyl optionally substituted with one or more fluorine atoms； and R3 is (1-4C) alkylene-R4 where the alkylene group may be substituted with one or more hal
