STULL, ROBERT A.,FOORD, ORIT,LIU, DAVID,TORGOV, MICHAEL,SHAO, HUI,SAUNDERS, LAURA,DYLLA, SCOTT J.
申请号：
CA3050672
公开号：
CA3050672A1
申请日:
2013.02.22
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
An increased expression of DLL3 in cancers provides a target for cancertreatment.Immunization of mice with DLL3 protein produced murine DLL3-bindingantibodies.Humanized versions of the antibodies were produced. Antibodies were shown tointernalize into cells. Antibodies were conjugated with cytotoxins to produceantibodydrug conjugates (ADCs) for use in treating cancer.
