Antibodies are provided that are modified to reduce the tendency to aggregate State, and Methods for producing such Antibodies.This also provides Antibodies specific for TNF scFv and fab Fragments of particularly stable and solubleInclude specific sequences of heavy chain and light chain optimized for Stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity.Also provided are Nucleic Acids, Vectors and host cells for expression of recombinant Antibodies, Methods to isolate and the use of such Antibodies in Medicine.Claim 1: an Antibody that specifically binds to human TNFa,Comprising: (a) a variable light chain comprising the sequence id no. or SEC 2 sec id no. 14； and (b) a heavy chain variable that includes the sequence id no. 5 sec.Винахід належить до антитіла, яке специфічно зв’язується з TNF-α та має зменшену здатність до агрегації, нуклеїнової кислоти, вектора та клітини-хазяїна для експресії вказаних антитіл та способів їх застосування у медицині.
