C-28 AMINES OF MODIFIED C-3-BETULIN ACID DERIVATIVES AS ANTI-HUMIDITY INHIBITORS

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专利权人:

BRISTOL-MYERS SQUIBB COMPANY

发明人:

REGUEIRO-REN, ALICIA,SWIDORSKI, JACOB,SIT, SING-YUEN,CHEN, YAN,CHEN, JIE,MEANWELL, NICHOLAS A.,LIU, ZHENG

申请号：

DK12702946

公开号：

DK2670764T3

申请日:

2012.01.27

申请国别(地区):

DK

年份:

2015

代理人:

摘要：

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-28 amines of C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS. In particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof: a compound of formula I a compound of formula II and a compound of formula III

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