David Chauvier,Richard Casimir,Etienne Jacotot,Dominique Rebouillat
申请号：
US11579202
公开号：
US08173600B2
申请日:
2005.05.02
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to selective new caspase-2 inhibitors that recognize caspase-2 and prevent and block its activity based on the following backbone: 2-Quinolinylcarbonyl-L-Valinyl-L-Aspartyl (methyl ester)-L-Valinyl-L-Alanyl-L-Aspartyl (methyl ester) 2,6-difluorophenyl ester SEQ ID NO:1) and derivatives thereof, SEQ ID NO:1 corresponding to formulae Ia or Ib. Application of the inhibitors for preventing and treating diseases involving caspase-2.
