Human microRNAs and methods for inhibiting same

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专利权人:

Rockefeller University

发明人:

Landgraf, Pablo,Tuschl, Thomas

申请号：

AU2006242225

公开号：

AU2006242225B2

申请日:

2006.05.01

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a microRNA shown in SEQ ID NOs: 1-94 281-374 467- 481 497-522 or 549, except that up to thirty percent of the bases may be wobble bases, and up to 10% of the contiguous bases may be non-complementary. The invention further relates to modified single stranded microRNA molecules, isolated single stranded anti-microRNA molecules and isolated microRNP molecules. In another embodiment, the invention relates to a method for inhibiting microRNP activity in a cell.

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中国工程科技知识中心

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