Keelung Hong,Wei Wen Zheng,Daryl C. Drummond,Dmitri B. Kirpotin,Mark Eamon Hayes
申请号：
US14502836
公开号：
US20150140069A1
申请日:
2014.09.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided herein is a process for preparing a microparticulate complex of a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible organic solvent. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component, and a composition comprising water and the microparticulate complex. Further provided is a method of delivery of a nucleicacid-like component to a cell or to a patient by contacting the cell with or administering to the patient a composition comprising water and the microparticulate complex described herein. Still further, a charge-changing composition represented by the formula A-X—B is provided.
