An endoscope treatment tool includes a pair of forceps members, a manipulation portion, and a manipulation wire connecting the pair of forceps members and the manipulation portion. The manipulation portion includes a manipulation portion main body, a shaft, a clutch plate having a through-hole into which the shaft is inserted, a bias spring configured to hold the through-hole and an the shaft such that an axis of the through-hole is parallel to an axis of the shaft, an inner slider connected to the manipulation wire and slidably attached to the manipulation portion main body and the shaft, an outer slider slidably attached to the inner slider, and a coil spring. A posture holding by the bias spring is released in accordance with compression of the coil spring, the clutch plate is inclined with respect to the shaft, and the inner slider is fixed to the manipulation portion main body.