PROCESS FOR THE PREPARATION OF APIXABAN

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专利权人:

发明人:

Brij KHERA,Kumar Kamlesh SINGH,Santosh Devidas DIWAKAR,Sunil Dnyaneshwar NARODE,Hiteshkumar Natwarlal SUTHAR

申请号：

US14950430

公开号：

US20160143894A1

申请日:

2015.11.24

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A crystalline Form N-1 of apixaban substantially free from one or more of: 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid 7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide or methyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate, relative to apixaban by area percentage of HPLC and having a mean particle size equal to or greater than 100 μm.

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