Disclosed herein are compositions and methods for treating a sigma-2 receptor-mediated condition or disorder, including treating one or more symptoms of a sigma-2 receptor-mediated condition or disorder.本文中公開用於治療σ-2受體介導之病況或病症,包括治療σ2受體介導之病況或病症之一或多種症狀的組合物及方法。