A cotton variety, designated 99M-548, the plants and seeds of the cotton variety 99M-548, methods for producing a cotton plant, either varietal or hybrid, produced by crossing the cotton variety 99M-548 with itself or with another cotton plant, and hybrid cotton seeds and plants produced by crossing the variety 99M-548 with another cotton variety or plant and to methods for producing a cotton plant containing in its genetic material one or more transgenes and to the transgenic cotton plants produced by that method. This disclosure also relates to cotton varieties derived from cotton variety 99M-548 including variety 548WRF-CB2-B, to methods for producing other cotton varieties derived from cotton variety 99M-548 and to the varieties derived by the use of those methods.