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New galectin inhibitors based on 3-triazolyl-galactoside
专利权人:
GALECTO BIOTECH AB
发明人:
LEFFLER, HAKON,SALAMEH, BADER ABDALRAHEEM BADER,NILSSON, ULF
申请号:
ES05741932
公开号:
ES2512501T3
申请日:
2005.05.23
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of the general formula (I): ** Formula ** wherein the pyranose ring configuration is D-galacto; X is selected from the group consisting of O and S; Y is selected from the group consisting of CH2, CO, SO2 and phenyl, or is a bond; R1 is selected from the group consisting of: a) glucose, mannose, galactose, N-acetylglucosamine, N-acetylgalactosamine, fucose, fructose, xylose, sialic acid, glucoronic acid, iduronic acid and galacturonic acid; b) D-galactose substituted with C3- [1,2,3] triazol-1-yl; and c) hydrogen, an alkyl group and an alkenyl group; and R2 is selected from the group consisting of hydrogen, an optionally substituted amino group, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted alkoxy group, an optionally substituted alkylamino group, an arylamino group optionally substituted, an optionally substituted aryloxy group, an optionally substituted aryl group and a heteroaryl group, wherein said optional substituents are halogen, alkyl, which in turn may be optionally substituted, alkoxy, nitro, sulfo, amino, hydroxy or carbonyl, wherein: the alkyl group is a straight or branched chain group comprising from 1 to 12 carbon atoms, or a cycle comprising from 3 to 12 carbon atoms; the alkenyl group is a group comprising from 2 to 12 carbon atoms and at least one double bond; the aryl group is a group comprising from 4 to 18 carbon atoms, such as a phenyl group or a naphthyl group; the alkoxy group is a group comprising from 1 to 12 carbon atoms; such as a methoxy group or an ethoxy group; the alkylamino group is a group comprising 1 to 12 carbon atoms; the arylamino group is a group comprising from 4 to 12 carbon atoms, such as aniline, carboxylated aniline or halogenated aniline; the aryloxy group is a group comprising from 4 to 12 carbon atoms, such as phenol, carboxylated phenol or halogenated phenol; and the heteroaryl group is a group comprising fro
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