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HETEROCYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DISEASE
专利权人:
INC.;EPIGEN BIOSCIENCES
发明人:
BEATON, GRAHAM,TUCCI, FABIO, C.,RAVULA, SATHEESH, B.,SHAH, CHANDRAVADAN, R.,LIU, HIEP
申请号:
SG11201507459Y
公开号:
SG11201507459YA
申请日:
2014.03.17
申请国别(地区):
SG
年份:
2015
代理人:
摘要:
Heterocyclic compounds are described that are lysophosphatidic acid receptor ligands that are useful in the treatment of lysophosphatidic acid receptor-dependent diseases and conditions, including but not limited to diseases involving fibrosis, such as fibrosis of the heart, kidney, liver and lung, and scleroderma; inflammatory diseases such as diabetic nephropathy and inflammatory bowel disease; ocular diseases such as diseases involving retinal degeneration; nerve diseases such as pruritus and pain. Non-limiting examples of those compounds include (RS)-3-Cyclopropyl-2-{4-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-benzyloxy}-propionic acid and (R)-1-(4′-{5-[1-(2-Chloro-phenyl)-ethoxycarbonylamino]-4-fluoro-pyrazol-1-yl}-2-fluoro-biphenyl-4-yl)-cyclopropanecarboxylic acid.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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