Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.本發明提供經修飾的因子VII多肽和其用途。該等經修飾的FVII多肽包括因子VIIa及因子VII之其他形式。所提供之經修飾的FVII多肽中,有具有經改變之活性(典型地經改變之促凝血活性,包括促凝血活性增強之彼等FVII多肽)者。因此,該等經修飾的多肽為治療劑。