A prosthesis arranged to be coupled to a bone. The prosthesis comprises a substrate (2) having a surface (6). The surface (6) of the substrate (2) has a first area and a second area, the first area being treated such that osteointegration is promoted more than in the second area. The interface (12) between the first and second areas forms an alignment mark to assist alignment of the prosthesis relative to a bone. The prosthesis is arranged to be at least partially inserted into a bone cavity such that the position of the alignment mark relative to the bone cavity is indicative of the angle of insertion of the prosthesis or the alignment mark provides a position reference for determining the implanted position of the prosthesis in the cavity. A method of manufacturing the prosthesis and a method of implanting the prosthesis are also provided.
