ДАДЛЕР Томас (US),ГОМБОТЦ Уэйн Р. (US),ПЭРЕНТ Джеймс Брайан (US),ТЕДФОРД Кларк Э. (US),КАВЛЬЕ Анита (NO),ХАГЕМАНН Урс Беат (NO),РЕЙЕРСЕН Херальд (NO),КИПРИЯНОВ Сергей (NO)
申请号：
RU2013153527/10
公开号：
RU2013153527A
申请日:
2012.05.04
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. An isolated human monoclonal antibody or antigen binding fragment thereof that binds to human MASP-2, wherein said antibody includes: I) a) a heavy chain variable region comprising: i) a heavy chain CDR-H1 comprising the amino acid sequence 31-35 of SEQ ID NO: 20； and ii) a heavy chain CDR-H2 comprising the amino acid sequence 50-65 of SEQ ID NO: 20； and iii) a heavy chain CDR-H3 comprising the amino acid sequence 95-102 of SEQ ID NO: 20； and b) a light chain variable region comprising: i) a light chain CDR-L1 comprising the amino acid sequence 24-34 of SEQ ID NO: 22 or SEQ ID NO: 24； and ii) a light chain CDR-L2 comprising the amino acid sequence 50-56 of SEQ ID NO: 22 or SEQ ID NO: 24； and iii) a light chain CDR-L3 comprising the amino acid sequence 89-97 of SEQ ID NO: 22 or SEQ ID NO: 24； and II) their variant, which is identical to the indicated variable domains, with the exception of those variants that contain all 10 amino acid substitutions in the specified CDR regions of the indicated variable region of the heavy chain and all 10 amino acid substitutions in the specified CDR regions of the indicated variable region of the light chain, where the specified an antibody or variant thereof inhibits MASP-2-dependent complement activation. 2. The antibody according to claim 1, wherein said antibody has at least one of the following functions, namely: (i) where said antibody binds to human MASP-2 with K = 10 nM or less； (ii) where said antibody binds to a domain CCP1 of the MASP-2 epitope； (iii) where the indicated antibody inhibits C3b deposition in an in vitro assay in 1% human serum at IC = 10 nM or less； (iv) where the indicated antibody inhibits C3b deposition in 90% human serum at IC = 30 nM or less； (v) where the specified antibody according to1. Выделенное человеческое моноклональное антитело или его антигенсвязывающий фрагмент, которые связываются с человеческим MASP-2, где указанное антитело включают:I) a) вариабельную область тяжелой цепи, содержащую:i
