PYRAZOLO[3,4-B]PYRIDINES AND IMIDAZO[1,5-B]PYRIDAZINES AS PDE1 INHIBITORS

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专利权人:

H. LUNDBECK A/S

发明人:

RASMUSSEN, Lars, Kyhn,KEHLER, Jan,JUHL, Karsten,MARIGO, Mauro,VITAL, Paulo, Jorge, Vieira,LANGGÅRD, Morten,JESSING, Mikkel

申请号：

CR20190302

公开号：

CR20190302A

申请日:

2017.12.20

申请国别(地区):

CR

年份:

2019

代理人:

摘要：

Current inventions provide a formula (I) compound for the inhibitory enzyme PDE1 and use it as a drug, especially for the treatment of neurodegenerative disorders and mental disorders. The invention also provides pharmaceutical ingredients including invented compounds and a method for treating disorders by using invented compounds.... Prescription (I) ingredients containing PDE1 enzymes inhibitors and their use as medicines are provided.In particular for the treatment of neurogradiative disorders and psychiatric disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.La presente invención proporciona compuestos de fórmula (I) que son inhibidores de la enzima PDE1 y su uso como un medicamento, en particular para el tratamiento de trastornos neurodegenerativos y trastornos psiquiátricos. La presente invención también proporciona composiciones farmacéuticas que comprenden compuestos de la invención y métodos para tratar trastornos utilizando los compuestos de la invenciónThe present invention provides compounds of formula (I) that are PDE1 enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.

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