Provided herein are methods for treating subjects having an EBV-associated cancer, including a relapsed or refractory solid tumor and Burkitts lymphoma, wherein the method comprises administering to the subject 5-azacytidine. In certain of the methods, 5-azacytidine is administered alone or in combination with one or more anti-cancer agents. In certain of the methods, 5-azacytidine is formulated in an oral dosage form and administered orally.