COLLARD, Joseph,KHORKOVA SHERMAN, Olga,COITO, Carlos
申请号：
USUS2011/048225
公开号：
WO2012/024478A3
申请日:
2011.08.18
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Nicotinamide Phosphoribosyltransferase (NAMPT), in particular, by targeting natural antisense polynucleotides of Nicotinamide Phosphoribosyltransferase (NAMPT). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of NAMPT.La présente invention concerne des oligonucléotides antisens qui modulent lexpression et/ou la fonction de la nicotinamide phosphoribosyltransférase (NAMPT), en particulier, en ciblant des polynucléotides antisens naturels de nicotinamide phosphoribosyltransférase (NAMPT). Linvention concerne en outre lidentification de ces oligonucléotides antisens et leur utilisation dans le traitement de maladies et troubles associés à lexpression de NAMPT.
