Tsuglenok Nikolaj Vasilevich (RU),Цугленок Николай Васильевич (RU),Kasparov Eduard Vilyamovich (RU),Каспаров Эдуард Вильямович (RU),Modestov Andrej Arsenevich (RU),Модестов Андрей Арсеньевич (RU),Tona
申请号：
RU2018125084
公开号：
RU0002723680C2
申请日:
2018.07.09
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention is intended for inducing death of tumor cells in living biological objects with high-conductivity solution of 5-aminolevulinic acid and electromagnetic HF and microwave energy of photo-wave radiation, known as HF and UHF hyperthermia. Described is a method for initiation of tumor cell death, intended for local treatment of cancer patients having tumor tissues in various organs of a human body, characterized by that before treatment, person for 3 days is transferred to a carbohydrate-free diet, to create a glucose "starvation" and subsequent maximum saturation of oncological cells with electron-ion solution of protoporphyrin IX 5-aminolevulinic acid preparation "Alasens" introduced into vein in megadosis 36 mg/kg of body weight for maximum accumulation in tumor tissues, in 10–15 times more than in healthy in 3–6 hours, selective hyperthermia of tumor tissue with UHF energy is performed in accordance with depth of their location and penetration depth of electromagnetic wave into human body 6.1 centimeters, at permitted frequency f=2450 MHz, with a total heating rate of tumor tissues of 0.06 °C/s for 180 sec to a tumor tissue temperature of 46.5 °C, while heating the healthy tissues does not exceed 40 °C.EFFECT: technical result is local destruction of deep-lying biotissues malignant growths at their HF and microwave heating and in secondary heating of border layers of tumor and healthy tissues due to high-temperature heat transfer from tumor tissues with minimal destruction of surrounding healthy cells of biological tissue.1 cl, 2 tblИзобретение относится к медицине и предназначено для индукции гибели опухолевых клеток в живых биологических объектах высокоэлектропроводящим раствором 5- аминолевулиновой кислотой и электромагнитной ВЧ и СВЧ энергией фотоволнового излучения, известное как ВЧ и СВЧ гипертермия. Описан способ инициации гибели опухолевых клеток, предназначенный для локального лечения онкологических больных, имеющих опухо
