NUEVOS DERIVADOS DE COMPUESTOS DE [3,2-C]PIRAZOL ESTEROIDAL CON ACTIVIDAD GLUCOCORTICOIDE

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专利权人:

ASTRAZENECA AB

发明人:

BLADH, HAKAN,BURKAMP, FRANK,GABOS, BALINT,HANSEN, PETER ROBERT

申请号：

PE0017582011

公开号：

PE06442012A1

申请日:

2010.04.01

申请国别(地区):

PE

年份:

2012

代理人:

摘要：

Refers to compounds of 2 - [c] pyrazole steroid such as: Metoxiacetato (1R, 2R, 3aS, 3BS, 10aS, 10br, 11S, 12aS) - 10b - fluoro - {[1 - (fluoromethyl) sulfanyl] carbonyl] - 7 - (6 - fluoropiridin - 3 - il) 11 Hydroxy Trimethyl 1,2,3,3a 2,10a, 12a, 3b, 4,5,7,10,10a, 10B, 11,12,12a - tetradecahidrociclopenta [5,6] na FTO [1,2] indazol F 1 - ILO -, propanoate (1R, 2R, 3aS, 3BS, 10aS, 10br, 11S,12aS) - 1 - [(cyanomethyl) sulfanyl] carbonyl} - 10b - fluoro - 7 - (6 - fluoropiridin - 3 - yl) - 11 Hydroxy Trimethyl 1,2,3,3a 2,10a, 12a, 3b, 4,5,7,10,10a, 10B, 11,12,12a - tetradecahidrociclopenta [5,6] Naphtho [1,2-c] indazol F - 1 ILO -, propanoate (1R, 2R, 3aS, 3BS, 10aS, 10br, 11S, 12aS) - 10b - fluoro - {[1 - (fluoromethyl) sulfanyl] carbonyl} - 7 - (4-fluorophenyl) - 11 Hydroxy Trimethyl 1,2,3,3a 2,10a, 12a, 3b, 4,5,7,10,10a, 10B, 11,12,12a - tetradecahidrociclopenta [5,6] Naphtho [1,2-c] indazol F - 1 - yl among others. It also relates to a Pharmaceutical composition. These compounds are useful as glucocorticosteroid receptor agonists in the treatment of Asthma, chronic obstructive pulmonary disease, allergic rhinitisSE REFIERE A COMPUESTOS DERIVADOS DE [3,2-c]PIRAZOL ESTEROIDAL TALES COMO: METOXIACETATO DE (1R,2R,3aS,3bS,10aS,10bR,11S,12aS)-10b-FLUORO-1-{[(FLUOROMETIL)SULFANIL]CARBONIL}-7-(6-FLUOROPIRIDIN-3-IL)-11-HIDROXI-2,10a,12a-TRIMETIL-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-TETRADECAHIDROCICLOPENTA[5,6]NAFTO[1,2-f]INDAZOL-1-ILO PROPANOATO DE (1R,2R,3aS,3bS,10aS,10bR,11S,12aS)-1-{[(CIANOMETIL)SULFANIL]CARBONIL}-10b-FLUORO-7-(6-FLUOROPIRIDIN-3-IL)-11-HIDROXI-2,10a,12a-TRIMETIL-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-TETRADECAHIDROCICLOPENTA[5,6]NAFTO[1,2-f]INDAZOL-1-ILO PROPANOATO DE (1R,2R,3aS,3bS,10aS,10bR,11S,12aS)-10b-FLUORO-1-{[(FLUOROMETIL)SULFANIL]CARBONIL}-7-(4-FLUOROFENIL)-11-HIDROXI-2,10a,12a-TRIMETIL-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-TETRADECAHIDROCICLOPENTA[5,6]NAFTO[1,2-f]INDAZOL-1-ILO ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA.

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