Inhibitors of metastasis, methods of generating such inhibitors and their therapeutic applications

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专利权人:

Girish V. Shah

发明人:

Girish V. Shah

申请号：

US14007683

公开号：

US09765115B2

申请日:

2012.03.30

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The chain of events that explains calcitonin receptor (CTR)-stimulated invasion and metastasis of prostate cancer cells was identified. The CTR-stimulated events depend on the interaction of CTR with the PDZ3 domain of ZO-1. Small peptides and small molecules were identified that inhibit this interaction. The small inhibitory peptides were synthesized and can be used to attenuate or inhibit metastasis in solid cancer tumors.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/