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NOUVEAUX COMPOSÉS UTILISÉS COMME INHIBITEURS DOUBLES D'HISTONE MÉTHYLTRANSFÉRASES ET D'ADN MÉTHYLTRANSFÉRASES
专利权人:
Fundacion para la Investigacion Medica Aplicada
发明人:
申请号:
EP15714185.4
公开号:
EP3154957B1
申请日:
2015.03.30
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
It relates to the use of compounds of formula (I'), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, as anticancer agents and as agents for generating induced pluripotent stem cells. Compounds of formula (I'), wherein R2' is an alcoxy group, a hydrocarbon chain or a ring system, and R1, R3, and R4 are as defined herein, are dual inhibitors of histone methyltransferases and DNA methyltransferases. It also relates to the compounds of formula (I'), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein R2' is phenyl or 5- to 6-membered heteroaromatic ring, both optionally fused to another rings (i.e., compounds of formula (I)). It also relates to pharmaceutical or veterinary compositions containing compounds of formula (I).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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