An apparatus configured to result in a penetration of one or more gasses into a dermis of biological skin, wherein the apparatus includes a fluid reservoir configured to contain an amount of a liquid in contact with a portion of a persons skin, and a nanobubble generator configured to inject nanobubbles into the liquid, wherein the nanobubbles contain the one or more gasses. The contact of the liquid containing the nanobubbles with the persons skin results in a cutaneous uptake of a gas contained in the nanobubbies into the persons skin, which may be beneficial in treating an ailment, such as diabetic peripheral neuropathy.
