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CORTICOSTEROID COMPOSITIONS FOR THE TREATMENT OF ESOPHAGEAL INFLAMMATION
专利权人:
MERITAGE PHARMA; INC.
发明人:
PHILLIPS, ELAINE,HILL, MALCOLM,DESHMUKH, HEMANT,JOHNSON, KEITH,LICALSI, CYNTHIA
申请号:
NZ58526808
公开号:
NZ585268A
申请日:
2008.11.12
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a stable oral pharmaceutical composition for treating or preventing esophageal inflammation or symptoms associated therewith comprising: a) a therapeutically effective amount of a topically active corticosteroid, the topically active corticosteroid being budesonide, fluticasone, mometasone furoate, ciclesonide, triamcinolone, beclomethasone, or a pharmaceutically acceptable ester or salt thereof, or a combination thereof, b) an antioxidant, c) a buffer, d) a surfactant, e) a preservative, a flavoring agent, a sweetener, or a combination thereof, f) at least one additional excipient that increases the interaction of the composition with a surface of the esophagus, g) dextrose in an amount of 0-500 mg per mL of the composition, and h) a liquid vehicle, wherein the composition is chemically and physically stable, wherein the composition remains substantially uniform for at least 1 day, and wherein the composition is suitable for single or multiple dose administration.
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