The invention relates to a solid dispersion comprising Coenzyme Q10 and a phospholipid in the presence of a cellulosic derivative and/or a polymeric material selected from the group consisting of polyvinylpyrrolidone polyvinyl acetate poly (methacrylic acid methyl methacrylate) poloxamers chitosan alginates hyaluronic acid pectin pullulan cyclodextrins starch polymers D alpha tocopheryl polyethylene glycol 1000 succinate.