Jason Allan Wiles,Avinash S. Phadke,Milind Deshpande,Atul Agarwal,Dawei Chen,Venkat Rao Gadhachanda,Akihiro Hashimoto,Godwin Pais,Qiuping Wang,Xiangzhu Wang
申请号：
US15245712
公开号：
US10005802B2
申请日:
2016.08.24
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R12 or R13 on the A group is an amide substituent (R32) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade in the alternative complement pathway. The inhibitors of factor D described herein reduce the excessive activation of complement.
