INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization MD 1111101110101011111 HO 11111 0111011100101111101110101111111011 III International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... .....!, WO 2017/132562 Al 3 August 2017 (03.08.2017) WI P0 I P CT (51) International Patent Classification: C12P 21/08 (2006.01) A61K 39/00 (2006.01) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (21) International Application Number: PCT/US2017/015429 RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (22) International Filing Date: ZA, ZM, ZW. 27 January 2017 (27.01.2017) (84) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (26) Publication Language: English TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (30) Priority Data: 62/288,912 29 January 2016 (29.01.2016) US TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventor and SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (71) Applicant : ZHOU, Heyue [CN/US] 15732 Potomac GW, KM, ML, MR, NE, SN, TD, TG). Ridge Road, San Diego, CA 92127 (US). Published: (74) Agents: HERRITT, Danielle, L. et al. McCarter & Eng- lish, LLP, 265 Franklin Street, Boston, MA 02110 (US). with international search report (Art. 21(3)) (81) Designated States (unless otherwise indicated, for every before the expiration of the time limit for amending the claims and to be republished in the event of receipt of kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN,
