THE RESEARCH FOUNDATION FOR STATE UNIVERSITY OF NEW YORK
发明人:
DILMANIAN, F., AVRAHAM
申请号：
CA3082878
公开号：
CA3082878A1
申请日:
2018.11.16
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
A method for treating damaged peripheral nerves of a subject includes irradiating at least a portion of the damaged PNs with an array of x-ray microbeams having an in-beam dose sufficient to at least initiate demyelination, each of the microbeams being no greater than 0.7 mm in thickness, and separated for tissue sparing, e.g., by at least.05 mm, and optionally administering Schwann cell progenitors (SCPs) to the irradiated portion to remyelination before or after irradiating. In-beam dose may be between about 30 to 200 Gy. The method may include irradiating using an x-ray tube of a CT scanner having a multi-aperture collimator mounted thereto and on/near the subject. The SCPs may be adult rat olfactory sphere cells or neural stem cells.
