A composition comprises tulathromycin and at least one non-steroidal anti-inflammatory drug (NSAID). Preferably the tulathromycin is a mixture of tulathromycin A and B isomers which may be present in a ratio of 9:1 (isomer A:B). The following compositions have been exemplified tulathromycin and carprofen； tulathromycin and firocoxib； tulathromycin and flunixin meglumine； and tulathromycin and meloxicam. Preferably the composition is useful in the treatment of respiratory diseases in mammals, in particular, pigs and cattle.
