THE REGENTS OF THE UNIVERSITY OF COLORADO; A BODY CORPORATE
发明人:
MAHALINGAM, Ravi,GILDEN, Donald
申请号：
USUS2013/059192
公开号：
WO2014/043189A1
申请日:
2013.09.11
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention is directed to a mutated recombinant herpesvirus, e.g., varicella zoster virus (VZV) and simian varicella virus strains or HSV-1 or HSV-2 strains, vaccines containing, and methods for the construction and use thereof to elicit protective immunity in susceptible individuals, wherein the particular herpesvirus is modified to render the virus replication deficient, i.e., the virus substantially or only replicates under defined conditions, by the incorporation of at least one destabilization domain in or fused to a gene essential for herpesvirus replication. The invention particularly relates to the use of the resultant conditionally replication defective herpesviruses, e.g., a mutated VZV strains in vaccine compositions in order to immunize individuals against herpesvirus infection, e.g., in the case of VZV chickenpox and to protect against shingles and zoster, or to prevent the reactivation of VZV or other herpesvirus reactivation and the onset of shingles or another condition relating to the reactivation of another herpesvirus infection, e.g., as a consequence of advanced age, stress, inflammation, drug or other therapy, cancer, or immunodeficiency such as in HIV-AIDS or other diseases resulting in impaired T and/or B cell immunity.La présente invention concerne un herpès virus recombinant muté, par exemple des souches de virus de varicelle-zona (VZV) et de virus de varicelle simienne ou des souches HSV-1 ou HSV-2, des vaccins les contenant et des procédés de construction et dutilisation associés pour déclencher une immunité protectrice chez des individus sensibles, lherpès virus particulier étant modifié pour rendre la réplication virale déficiente, cest-à-dire que le virus se réplique sensiblement ou uniquement dans des conditions définies, par lincorporation dau moins un domaine de déstabilisation dans un gène essentiel ou fusionné à celui-ci pour la réplication de lherpès virus. Linvention concerne en particulier lutilisation des herpès viru
