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Neurotoxins exhibiting shortened biological activity
专利权人:
Jurgen Frevert;Fred Hofmann
发明人:
Fred Hofmann,Jurgen Frevert
申请号:
US13381533
公开号:
US08586329B2
申请日:
2010.07.01
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein the polypeptide comprises at least one degradation signal in the light chain of the neurotoxin polypeptide as well as vectors and host cells comprising the polynucleotide, polypeptides encoded thereby and antibodies specifically binding to the polypeptides. Moreover, the invention relates to medicaments comprising the polynucleotides and polypeptides, as well as specific therapeutic applications thereof. Furthermore, the present invention contemplates methods for the manufacture of the polypeptides and medicaments.
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