Федеральное государственное бюджетное учреждение науки Институт биофизики клетки Российской академии наук (ИБК РАН) (RU)
发明人:
Бобкова Наталья Викторовна (RU),Овчинников Лев Павлович (RU),Медвинская Наталия Игоревна (RU),Гурьянов Сергей Георгиевич (RU),Нестерова Инна Владимировна (RU),Елисеева Ирина Александровна (RU),Самохин
申请号：
RU2013139704/15
公开号：
RU2013139704A
申请日:
2013.08.28
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method of treating neurodegenerative diseases in a subject in need thereof, comprising intranasally administering to the subject a therapeutically effective amount of protein YB-1 and / or its active fragment and / or a proizvodnogo.2. A method according to Claim. 1, comprising intranasal administration of a therapeutically effective amount of the active fragments of the protein YB-1 or proizvodnyh.3. . A method according to claim 1, wherein neirodegenerativnoe disease associated with abnormal protein synthesis and is a group: Alzheimers disease, Parkinsons disease, Huntingtons chorea, senile dementia, vascular dementia, dementia with Lewy bodies, frontotemporal dementia, mixed dementia, Creutzfeldt disease Jacobi, normal pressure hydrocephalus, Wernicke-Korsakoff syndrome, multiple sclerosis, cognitive impairment, prion zabolevaniya.4. A method according to Claim. 1 in which YB-1 is a full length protein YB-1.5. . A method according to claim 1, wherein the YB-1 protein having the amino acid sequence of human SEQ ID NO: 1 and rabbit SEQ ID NO: 7.6. . A method according to claim 1, wherein the active fragment of the protein YB-1imeet amino acid sequence of human SEQ ID NO: 3 and rabbit SEQ ID NO: 9.7. . A method according to claim 1, wherein the active fragment of the protein YB-1imeet amino acid sequence of human SEQ ID NO: 5 and rabbit SEQ ID NO: 11.8. A method according to Claim. 1, wherein the protein YB-1 and / or its active fragment and / or derivative thereof is used in a therapeutically effective amount either alone or in a composition, further comprising one or more agents that enhance intranasal delivery composition mozg.9. A method according to Claim. 1, wherein the protein YB-1 and / or its active fragment and / or derivative thereof are included in the composition,1. Способ лечения нейродегенеративных заболеваний у субъекта, нуждающегося в этом, включающий интраназальное введение субъекту терапевтически эффективного количества белка YB-1 и/или его а
