The present disclosure provides antibodies specific for an epitope present on CD22. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided. An anti -CD22 antibody of the present disclosure can in some cases induce apoptosis in a cell that expresses CD22 on its cell surface. A subject antibody specifically binds a CD22 polypeptide, where the epitope comprises amino acid residues within a CD22 antigen (e.g., within amino acids 1 to 847, within amino acids 1-759, within amino acids 1 - 751, or within amino acids 1 -670, of a CD22 amino acid sequence).
