Pharmaceutical compositions and single unit dosage forms of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, or a pharmaceutically acceptable stereoisomer, prodrug, salt, solvate, hydrate, or clathrate, are provided herein. Also provided are methods of treating, managing, or preventing various disorders, such as cancer, an inflammatory disease and/or an immune-related disorder.本文提供3-(5-胺基-2-甲基-4-側氧基-4H-喹唑啉-3-基)-哌啶-2,6-二酮或醫藥上可接受之立體異構物、前藥、鹽、溶劑合物、水合物或晶籠化合物之醫藥組合物及單一單位劑型。亦提供治療、管控或預防各種病症(諸如癌症、發炎疾病及/或免疫有關病症)的方法。