#$%^&*AU2020213313A120200827.pdf#####ABSTRACT This invention relates to methods of treating B-cell malignancies using a combination of inhibitors of JAKI and/or JAK2 and inhibitors of P3K6.1/8 00 00 E I - i oz (I a) ) E Zr (p <;~ (AAa- AA a- CA - I4 II a) a) -j -j -j (NIC _ -1 6 m - Ue a)I V) a) (N V.) 4-JO