BUECHLER, KENNETH F.,WHITTAKER, MICHAEL,REYNOLDS, MARK,SCOTT, CHRISTOPHER A.
申请号：
CA2535971
公开号：
CA2535971C
申请日:
2004.08.19
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention describes compositions and methods designed to determinethe presence or amount of biologicallyactive natriuretic peptides, or their fragments, in a sample. The degradationof natriuretic peptides is an ongoing process thatmay be a function of, inter alia, the elapsed time between onset of an eventtriggering natriuretic peptide release into the tissues andthe time the sample is obtained or analyzed, the quantity of proteolyticenzymes present, etc. This degradation can produce circulatingamounts of natriuretic peptides having reduced or lost biological function.The present invention provides, inter alia, assaysdesigned to accurately measure biologically active natriuretic peptides, andcompositions to inhibit a previously unknown pathwayfor degradation of natriuretic peptides.
