Devices, systems, and methods directed to evaluating a vessel of a patient are provided. The method includes outputting, to a display, a screen display including: a visual representation of a pressure ratio of pressure measurements obtained by first and second instruments positioned within a vessel while the second instrument is moved longitudinally through the vessel and the first instrument remains stationary within the vessel； and a visual representation of the vessel； receiving a user input to modify one of the visual representations of the pressure ratio and the vessel to simulate a therapeutic procedure； and updating the screen display, in response to the user input, including: modifying the selected one of the visual representation of the pressure ratio and the vessel based on the received user input； and correspondingly modifying the unselected one of the visual representation of the pressure ratio and the vessel.
