SUN, JEONGHOON,宣廷勳,TAM, LEI-TING TONY,谭利庭,譚利庭,HAN, HQ,韩奎,韓奎,KWAK, KEITH SOO-NYUNG,郭凯斯守良,郭凱斯守良,ZHOU, XIAOLAN,周孝兰,周孝蘭
申请号：
TW103117408
公开号：
TWI573802B
申请日:
2008.03.05
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The present invention provides variant activin IIB soluble receptors polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides. Compositions and methods for treating muscle-wasting and metabolic and other diseases and disorders are also provided.本發明提供能結合並抑制活動素A、肌肉生長抑制素或GDF-11活性之變異之活動素IIB可溶性受體多肽。本發明也提供能製造變異之多肽之多核苷酸、載體及宿主細胞。也提供用於治療肌肉消瘦及代謝以及其他疾病與失調之組成物及方法。
