A system improves analysis, diagnosis and characterization of cardiac function signals (including surface ECG signals and intra-cardiac electrograms) based on cardiac electrophysiological activity momentum computation, characterization and mapping. The system calculates an electrophysiological signal momentum of different portions of cardiac signals including a timing, location and severity of cardiac pathology and improves reliability of diagnosis, detection, mapping to an identified medical condition, and characterization. The system improves identification of cardiac disorders, differentiation of cardiac arrhythmias, characterization of pathological severity, prediction of life-threatening events and supports evaluation of drug administration effects.