Abizer I. Harianawala;Louis Brenner;Jeffrey M. Goldberg;Hitesh R. Bhagat
发明人:
Hitesh R. Bhagat,Jeffrey M. Goldberg,Abizer I. Harianawala,Louis Brenner
申请号：
US13183079
公开号：
US08808738B2
申请日:
2011.07.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37° C. and at pH of at least 1 for a period of at least ten weeks at 60° C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.
